TABLE 1.
Staphylococcal surface proteins and secreted proteins carrying the YSIRK-G/S motif
| Genea | LPXTGb motif | YSIRK-G/Sc motif | Sequence | Reference |
|---|---|---|---|---|
| clfA | + | + | HAIRKKSIGVAS | 31 |
| clfB | + | + | YSIRRFTVGTTS | 35 |
| fnbA | + | + | YGIRKHKLGAAS | 52 |
| fnbB | + | + | YGIRKHKLGAAS | 21 |
| mrp | + | + | FSIRKFNVGIFS | 70 |
| pls | + | + | YSIRRFTVGTAS | 30 |
| sdrC | + | + | FSIRKYSVGTAS | 22 |
| sdrD | + | + | FSIRKYTVGTAS | 22 |
| sdrE | + | + | FSIRKYTVGTAS | 22 |
| spa | + | + | YSIRKLGVGIAS | 64 |
| sasC | + | + | YSIRKYKVGIFS | 30 |
| sasE | + | + | SAMKKITMGTAS | 30 |
| sasG | + | + | YSIRKFTVGTAS | 30 |
| sasI | + | + | YSIRKSTLGVAS | 30 |
| sasJ | + | + | YSIRKSSLGVAS | 30 |
| cna | + | − | 38 | |
| sasA | + | − | 30 | |
| sasF | + | − | 30 | |
| sasH | + | − | 30 | |
| sasK | + | − | 30 | |
| sasL | + | − | 30 | |
| sasM | + | − | 30 | |
| geh1 | − | + | YSIRKYSIGVVS | 44 |
| geh2 | − | + | YSIRKFSVGASS | 44 |
| embB | − | + | FSIRKYTVGTFS | 25 |
| lytN | − | + | YSIRKVSIGILS | 25 |
a
Sas denotes S. aureus surface protein (29).
b
Sortase cleavage site. L, leucine; P, proline; X, any amino acid; T, threonine; G, glycine. Sortase cleaves between T and G.
c
(F/Y)SIRKXXXGXXS. F, phenylalanine; Y, tyrosine; S, serine; I, isoleucine; R, arginine; K, lysine; X, any amino acid; G, glycine.