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The effect of endocytic effectors on β-cleavage and Aβ secretion. N2a cells expressing CFP-swAPP and the dynaminK44A mutant (DynIIDN) or rab4wt constructs were assayed for sAPPβ, Aβ, and full-length APP as described in Materials and Methods. The y axis represents the amount of sAPPβ as a fraction of full-length APP (sAPPβ/APP) (black) or Aβ as a fraction of full-length APP (Aβ/APP) (magenta). The GFP control was normalized to 100%.
