Fig. 2.

Colon inflammation activity in WT and fat-1 transgenic mice. (A) Macroscopic view (Upper) and microscopic hematoxylin and eosin staining (Lower) of the distal colon in WT control mice (Left), DSS-treated WT nontransgenic littermates (Center), and fat-1 mice (Right). (B) Colon shortening as a hallmark of DSS-induced colonic damage is reduced in fat-1 mice. ∗, P < 0.01 versus WT DSS-treated animals. (C) Histopathological scores for colonic inflammatory infiltration and epithelial damage in WT and fat-1 mice. ∗, P < 0.01 versus WT DSS. (D) Body weight change from 100% baseline over 8 days in fat-1 mice and WT littermates (n = 6 for each group), 5 days of DSS treatment and 3 days of normal drinking water. ∗, P < 0.05 versus WT DSS; ∗∗, P < 0.01 versus WT DSS. Mice were killed on day 8 (arrow), and samples were taken for further analysis.