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. 2006 Jul 17;103(30):11276–11281. doi: 10.1073/pnas.0601280103

Fig. 4.

Fig. 4.

Markers of inflammation and mucoprotection. (A) NF-κB activation reflected in p65 ELISA activity shows significant differences in control baselines and in disease between WT and fat-1 mice. ∗, P < 0.05 versus WT DSS; ∗∗, P < 0.05 versus WT control. (B–F) Semiquantitative real-time PCR analysis of mRNA expression levels of inflammatory mediators TNFα, inducible NO synthase (iNOS), and IL-1β (B–D) and mucoprotective factors Tollip and TFF3 (E and F) in colons from WT and fat-1 mice after DSS exposure and fat-1 control mice, normalized as fold increase to the baseline of WT controls (dashed line). ∗, P < 0.05 versus WT DSS; ∗∗, P < 0.01 versus WT DSS. (G) ZO-1 expression profile. Compared with WT mice without treatment (Left), ZO-1 expression is down-regulated on the luminal epithelial surface in WT mice on day 4 (Center), whereas luminal continuity of expression is sustained in fat-1 mice (Right).