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Reduced cell proliferation, invasive, and metastatic capacity of anti-TER ribozyme-expressing B16 cells. (A) Growth curves measuring cell counts over 96 h for pooled vector, pooled ribozyme (Rz), and ribozyme clone 5 cells. (B) Quantitation of tumor cell invasion into Matrigel. (C) Total tumor counts in the lungs of mice i.v. injected with pooled vector, pooled ribozyme, and ribozyme clone 5 B16 cells.
