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. 2006 Jul 14;103(30):11323–11328. doi: 10.1073/pnas.0604772103

Fig. 2.

Fig. 2.

Relative bile acid concentrations of CDCA and its metabolites decrease in FXR-null BDL mice. Bile acid concentrations were measured 6 days after BDL or sham operation. (A) Total serum bile acids increased after BDL in all genotypes but were reduced in FXRKO relative to WT BDL mice. (B) Individual serum bile acids were quantitated by liquid chromatography/MS and expressed as a percentage of WT BDL concentration. Serum tauro-cholic acid (TCA), Tβ-MCA, and tauro-chenodeoxycholic acid (TCDCA) were significantly reduced in FXRKO mice; TCDCA and Tβ-MCA were reduced in P/FXRKO mice, but TCA concentrations were preserved in this genotype. (C) Individual hepatic bile acids were quantitated by liquid chromatography/MS and expressed as a percentage of WT BDL concentration. All FXR-null genotypes had a significant relative reduction in TCDCA and Tβ-MCA relative to WT BDL, whereas concentrations of TCA were preserved. #, P < 0.01 relative to WT BDL.