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. 2006 Jul 14;103(30):11323–11328. doi: 10.1073/pnas.0604772103

Fig. 3.

Fig. 3.

FXRKO mice have a biphasic lipid profile after BDL with marked hypertriglyceridemia. Blood samples were collected from mice before BDL or sham operation on day 0 and day 6. (A) Total cholesterol concentrations were similar in all sham mice. (B) After BDL, total cholesterol increased significantly in WT mice (P < 0.01). In FXRKO mice, a transient increase at day 3 was followed by a decline to less than one-half of WT levels by day 6. PXRKO mice also had an attenuated increase in total cholesterol. (C) Serum HDL cholesterol was significantly higher at baseline in FXRKO mice. (D) After BDL, FXRKO mice had a biphasic HDL cholesterol profile, with a transient decrease in HDL on day 3 and subsequent increase by day 6. (E) Fasting serum triglycerides in sham animals showed no genotype-specific differences by using the Cholestech LDX Analyzer. (F) After BDL, a marked increase in serum triglycerides was observed in FXR-null mice. (G) FXR regulates expression of apoAV. Relative mRNA expression of apolipoprotein genes in liver were examined by real-time RT-PCR. apoAV is induced in WT BDL mice, and its expression depends on FXR.