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. 2006 Jul 13;103(30):11329–11333. doi: 10.1073/pnas.0604616103

Fig. 5.

Fig. 5.

SRPIN340 suppresses the propagation of Sindbis virus. The Sindbis virus (strain TE) was prepared from the culture supernatant of BHK as described in ref. 29. (A–D) Vero cells were mock-infected (A and C) or were infected with Sindbis virus (B and D) at a multiplicity of infection of 1–10 plaque-forming units per cell. After 20 h of incubation with DMSO (A and B) or 40 mM SRPIN340 (C and D), phase contrast images were captured. (E) The inhibitory effect of SRPIN340 on the Sindbis virus propagation was quantified by plaque assay. Vero cells were infected with Sindbis virus (strain TE) with the indicated concentrations (10, 30, 50, and 100 μM) of SRPIN340 or with DMSO as a control. After 4 days, titers of virus infectivity were determined as described in ref. 29. (F) The data of three independent assays were shown in a graph with standard deviations.