Fig. 7.

Nonequilibrium binding of NF-κB to a downstream gene. The plot shows the peak gene activity as a function of IKK concentration, with k_off = 1/260 min⁻¹ kept fixed (1/k_off is twice the time period of oscillations). k_on ≈ 0.04, 0.015, and 0.004 μM⁻²·min⁻¹ for circles, asterisks, and squares, respectively.