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Structures and cellular targets of vancomycin and ramoplanin. (A) Structures of compounds discussed in the text. (B) The extracellular stage of PG biosynthesis. Vancomycin recognizes d-Ala-d-Ala (red); ramoplanin recognizes diphospho-MurNAc (blue). In B. subtilis, L-Lys is replaced with meso-diaminopimelic acid.
