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F-244 structure and overall architecture of HMGS. (A) Structure and stereochemistry of F-244. (B) The HMGS homodimeric architecture (blue and rose) and the extra 30-residue insertion forming a helical subdomain (gold) are shown. F-244 is depicted as van der Waals spheres with oxygen in red, carbon in gray in the left monomer, and carbon in blue in the right monomer.
