Degree distribution of Y2H PPIs. Number of proteins, N, with a given number of links from Y2H screen of H. pylori (8), the malaria parasite P. falciparum (6), yeast S. cerevisiae (5, 11), worm C. elegans (7), fruit fly D. melanogaster (4), and human (9, 10) proteins, shown as dots, was used to model by simulation (open circles) and semianalytical approaches (solid line).