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Alkylation of the cysteine at 338 abolished the irreversible inhibition by [Au(CN)2]−. An oocyte expressing T338C/wt CFTR was exposed to 1 mM 2-ME (open circles); 100 μM [Au(CN)2]− (solid circles) irreversibly reduced gCl by ∼80%. After reversing inhibition (1 mM 2-ME) and exposure to 100 μM IAM (shaded circles), the same concentration of [Au(CN)2]− induced a reversible, 20% decrease in gCl.
