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[Au(CN)2]− reversibly blocked Cys-less CFTR single-channel currents. (A) Currents recorded from detached, inside out patches (50 units PKA, 40 μM ATP) with symmetric 200 mM [Cl]−, pH = 6.0, at −100 mV and +100 mV in the presence of the indicated concentrations of [Au(CN)2]−. (B) Exposure to [Au(CN)2]− produced a voltage-dependent block of Cys-less CFTR channels indicative of a reversible interaction of the pseudohalide with the channel.
