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. 2006 Jun 9;91(5):1737–1748. doi: 10.1529/biophysj.105.078899

FIGURE 7.

FIGURE 7

[Au(CN)2]− irreversibly blocked T338C/Cys-less CFTR single-channel currents. (A) Single-channel currents recorded as in Fig. 6 with 200 μM ATP, illustrating multiple current amplitudes commonly seen in constructs containing cysteine at 338. (B) Exposure to 100 μM [Au(CN)2]− abolished single-channel currents. (C) Washing out [Au(CN)2]− did not reverse inhibition. (D) Reversal of inhibition by exposure to KCN (1 mM). The bottom panels (A1–D1) contain amplitude distributions of current levels for the corresponding traces shown in panels A–D.