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Synthetic thiolactone peptides are biologically active. Shown are representative data for activation (A) and inhibition (B) of the agr response by a synthetic thiotactone peptide. Degree of activity based on β-lactamase activity shown as a plot of Vmax versus peptide concentration. (A) Activation of the agr response in group II S. aureus cells by synthetic AgrDII. (B) Inhibition of the agr response in group I S. aureus cells by synthetic AgrDII.
