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. Author manuscript; available in PMC: 2006 Aug 16.
Published in final edited form as: Ann N Y Acad Sci. 2005 Dec;1061:55–64. doi: 10.1196/annals.1336.007

FIGURE 3.

FIGURE 3

SF-1 function in rescue mice. (A) Normal development of adrenal glands (a) and testes (t) in line 14 rescue mice (right) compared with absence of adrenal glands and gonads and persistence of müllerian duct in SF-1 null mice (left). (B) Anatomical evaluation of lines 7 and 14 rescued mice revealed differences in the ability of their transgenes to rescue SF-1 function in the null mice. Significantly smaller testes and seminal vesicles size were registered in line 7 rescue mice compared with wild-type (WT) littermates, whereas testes and seminal vesicle weights were equivalent in WT and line 14 rescue animals. (C) Immunodetection of transgenic SF-1 in line 14 rescue mice and endogenous SF-1 in WT mice. Similar SF-1 expression was observed in Sertoli (arrowhead) and Leydig cells (arrow) of rescue and WT testes as well as similar expression pattern indicated in VMH of rescue and WT animals.