Figure 2.

Transplantation of T cell–depleted NOD-PI BM prevents insulitis but not sialitis. (a) Islets free of inflammatory infiltrate (insulitis) were common in recipients of NOD-PI BM, and infiltration was restricted to the periphery of islets (arrow). (b) Extensively infiltrated islets (indicated by asterisks) were common in recipients of NOD BM. (c) The insulitis score was significantly reduced (P = 0.008) in recipients of T cell–depleted NOD-PI BM cells (triangles, 1.0 ± 0.6) as compared with NOD BM cells (inverted triangles, 2.1 ± 0.8 [means ± SD]). Data for age-matched NOD mice (squares) and NOD-PI mice (diamonds) are included for comparison. (d) The number of submandibular gland inflammatory foci (sialitis score) did not differ between BMT and untreated mice. Individual mouse scores are pooled from two experiments in which BMT from NOD and NOD-PI mice was performed in parallel (horizontal bar indicates mean).