Figure 1.

Dose-response study of the effects of DALDA and DAMGO on TNBS-induced colitis. The anti-inflammatory effects of different doses of DALDA (a) and DAMGO (b) given in preventive mode, once daily by subcutaneous administration, were assessed in mice sacrificed 4 days after TNBS administration. Colitis severity was evaluated by mortality rates, expressed as percentages (open circles), and by the intensity of macroscopic lesions (filled circles, mean ± SEM), assessed using the Wallace score. The different doses of agonists and the number of mice receiving each dosage are indicated. *P < 0.001, ^§P < 0.01, and ^†P < 0.05 in treated mice versus untreated mice with colitis.