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. 2003 May 1;111(9):1329–1338. doi: 10.1172/JCI16750

Figure 9.

Figure 9

MOR regulates expression of inflammatory and immunoregulatory cytokines in the colon. (a and b) Quantification of TNF-α, IL-4, and IFN-γ mRNA concentrations in the healthy colon of (a) Balb/c mice receiving vehicle (C) for 8 days, the MOR agonist DALDA (D) for 8 days, or the opioid antagonist NM administered subcutaneously for 10 consecutive days and in colon of (b) adult MOR–/– mice and their wild-type littermates. (c) Quantification of inflammatory cytokine levels four days after treatment in the colon of Balb/c mice receiving vehicle only (Control), TNBS only, or DALDA followed 4 days later by TNBS. (d) Quantification of inflammatory cytokine levels in the colon 4 weeks after T cell transfer in control SCID mice reconstituted with both CD4+CD45RBlo and CD45RBhi T cells (Hi + Lo) and in SCID mice with colitis reconstituted with CD4+CD45RBhi T cells without any treatment (Hi) or after subcutaneous administration of DALDA (10–2 mg/kg/d) (Hi + D) or DAMGO (10–3 mg/kg/d) (Hi + Do). The number of mice and statistical significance are indicated and results are expressed as mean ± SEM.