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. 1999 Feb 16;96(4):1234–1239. doi: 10.1073/pnas.96.4.1234

Figure 6.

Figure 6

A model for NFκB activation by the CD40cyt. There are two domains (cyt-N and cyt-C) in the CD40cyt for the NFκB activation. The cyt-N domain activates the NFκB through TRAF6 and the contribution to the activation by this domain is approximately 70%, whereas the cyt-C domain activates the NFκB through TRAF2 and/or TRAF5 and the contribution to the activation is approximately 30%. Although the NFκB activation by the cyt-C domain is thought to be mediated mainly by NIK, it is possible that the NFκB activation by cyt-N is mediated by an unknown molecule (kinase) in addition to NIK.