Table 2.
Equivalent and quasi-equivalent intertrimer interactions in dodecahedral and cubic E2p cores of PDH multienzyme complexes
| Interactions | Dodecahedral E2p core from B. stearothermophilus | Dodecahedral E2p core from E. faecalis | Cubic E2p core from A. vinelandii (refs. 11 & 12) |
|---|---|---|---|
| Quasi-equivalent | |||
| Hydrophobic anchor | |||
| Met-425-r | Met-537-r | Leu-637-r | |
| Residues involved in lining the hydrophobic pocket | |||
| His-237-b | His-348-b | Phe-449-b | |
| Phe-241-b | Phe-352-b | Gln-453-b | |
| Ile-244-b | Val-355-b | Val-456-b | |
| Leu-252-b | Leu-363-b | Leu-464-b | |
| Ile-314-b | Met-425-b | Leu-526-b | |
| Phe-315-b | Phe-426-b | Leu-527-b | |
| Equivalent | |||
| Backbone hydrogen bond shared among dodecahedral and cubic cores | |||
| Donor | Ile-314-b | Met-425-b | Leu-526-b |
| Acceptor | Leu-424-r | Met-536-r | Leu-636-r |
| Backbone hydrogen bond shared among dodecahedral and cubic cores | |||
| Donor | Phe-315-b | Phe-426-b | Leu-527-b |
| Acceptor | Met-425-r | Met-537-r | Leu-637-r |
The suffix “b” refers to the blue subunits, the suffix “r” to the red subunits in Fig. 2.