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. 1979 Dec;54(12):946–949. doi: 10.1136/adc.54.12.946

Maturation of caffeine elimination in infancy.

J V Aranda, J M Collinge, R Zinman, G Watters
PMCID: PMC1545746  PMID: 533298

Abstract

The developmental changes in caffeine elimination were studied in 7 infants aged between 2 1/2 weeks and 6 months. Adult plasma clearance rate of caffeine was achieved at 3 to 4 1/2 months of age. Plasma half-life and elimination rate reached adult levels after 3 to 4 1/2 months and seemed to exceed adult capacity thereafter. No significant changes in apparent volume of distribution were noted. Our data provide some indication of the age in infancy when the low rates of caffeine elimination in the neonate increase to the adult rate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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