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. 1979 Aug;54(8):587–592. doi: 10.1136/adc.54.8.587

Role of viruses and bacteria in acute wheezy bronchitis in childhood: a study of sputum.

M E Horn, S E Reed, P Taylor
PMCID: PMC1545792  PMID: 507912

Abstract

Sputum, nasal swabs, and throat swabs were obtained from 22 children aged between 5 and 15 years during 72 attacks of wheezy bronchitis. A virus, most commonly a rhinovirus, was isolated in 49% of all episodes and in 64% of 22 severe episodes requiring treatment with corticosteroids; the isolation rate was higher early in the illness than later. Virus was recovered more often from sputum than from the nose or throat, suggesting that viral replication occurs freely in the lower respiratory tract: the cytological findings in sputum were compatible with an inflammatory response to viral infection. Pathogenic bacteria appeared to play a minor role compared with viruses, and routine antibiotic treatment was probably of little value in moost cases. The significance of the results is discussed in relation to the pathogenesis of childhood wheezy bronchitis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blair H. T., Greenberg S. B., Stevens P. M., Bilunos P. A., Couch R. B. Effects of rhinovirus infection of pulmonary function of healthy human volunteers. Am Rev Respir Dis. 1976 Jul;114(1):95–102. doi: 10.1164/arrd.1976.114.1.95. [DOI] [PubMed] [Google Scholar]
  2. Cate T. R., Roberts J. S., Russ M. A., Pierce J. A. Effects of common colds on pulmonary function. Am Rev Respir Dis. 1973 Oct;108(4):858–865. doi: 10.1164/arrd.1973.108.4.858. [DOI] [PubMed] [Google Scholar]
  3. Empey D. W., Laitinen L. A., Jacobs L., Gold W. M., Nadel J. A. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 1976 Feb;113(2):131–139. doi: 10.1164/arrd.1976.113.2.131. [DOI] [PubMed] [Google Scholar]
  4. Fridy W. W., Jr, Ingram R. H., Jr, Hierholzer J. C., Coleman M. T. Airways function during mild viral respiratory illnesses. The effect of rhinovirus infection in cigarette smokers. Ann Intern Med. 1974 Feb;80(2):150–155. doi: 10.7326/0003-4819-80-2-150. [DOI] [PubMed] [Google Scholar]
  5. Godfrey S., Kamburoff P. L., Nairn J. R. Spirometry, lung volumes and airway resistance in normal children aged 5 to 18 years. Br J Dis Chest. 1970 Jan;64(1):15–24. doi: 10.1016/s0007-0971(70)80045-6. [DOI] [PubMed] [Google Scholar]
  6. Hall W. J., Douglas R. G., Jr, Hyde R. W., Roth F. K., Cross A. S., Speers D. M. Pulmonary mechanics after uncomplicated influenza A infection. Am Rev Respir Dis. 1976 Feb;113(2):141–148. doi: 10.1164/arrd.1976.113.2.141. [DOI] [PubMed] [Google Scholar]
  7. Horn M. E., Brain E. A., Gregg I., Inglis J. M., Yealland S. J., Taylor P. Respiratory viral infection and wheezy bronchitis in childhood. Thorax. 1979 Feb;34(1):23–28. doi: 10.1136/thx.34.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Horn M. E., Brain E., Gregg I., Yealland S. J., Inglis J. M. Respiratory viral infection in childhood. A survey in general practice, Roehampton 1967-1972. J Hyg (Lond) 1975 Apr;74(2):157–168. doi: 10.1017/s0022172400024220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ida S., Hooks J. J., Siraganian R. P., Notkins A. L. Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J Exp Med. 1977 Apr 1;145(4):892–906. doi: 10.1084/jem.145.4.892. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lambert H. P., Stern H. Infective factors in exacerbations of bronchitis and asthma. Br Med J. 1972 Aug 5;3(5822):323–327. doi: 10.1136/bmj.3.5822.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. McIntosh K., Ellis E. F., Hoffman L. S., Lybass T. G., Eller J. J., Fulginiti V. A. The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J Pediatr. 1973 Apr;82(4):578–590. doi: 10.1016/S0022-3476(73)80582-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Minor T. E., Dick E. C., DeMeo A. N., Ouellette J. J., Cohen M., Reed C. E. Viruses as precipitants of asthmatic attacks in children. JAMA. 1974 Jan 21;227(3):292–298. [PubMed] [Google Scholar]
  13. Mitchell I'Inglis H., Inglis H., Simpson H. Viral infection in wheezy bronchitis and asthma in children. Arch Dis Child. 1976 Sep;51(9):707–711. doi: 10.1136/adc.51.9.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Scott E. J., Grist N. R., Eadie M. B. Rhinovirus infections in chronic bronchitis: isolation of eight possibly new rhinovirus serotypes. J Med Microbiol. 1968 Aug;1(1):109–117. doi: 10.1099/00222615-1-1-109. [DOI] [PubMed] [Google Scholar]
  15. Stenhouse A. C. Rhinovirus infection in acute exacerbations of chronic bronchitis: a controlled prospective study. Br Med J. 1967 Aug 19;3(5563):461–463. doi: 10.1136/bmj.3.5563.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Strizova V., Brown P. K., Head B., Reed S. E. The advantages of HeLa cells for isolation of rhinoviruses. J Med Microbiol. 1974 Nov;7(4):433–438. doi: 10.1099/00222615-7-4-433. [DOI] [PubMed] [Google Scholar]

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