Figure 8.

PDEδ is highly conserved. Amino acid sequence alignment of PDEδ from bovine (bt_PDEδ; GenBank accession no. U65073), human (hs_PDEδ; GenBank accession no. AF022912), mouse (mm_PDEδ; GenBank accession no. AA726559) and C. elegans (ce_PDEδ; GenBank accession no. U14635). The sequence identity ranges from 70% to 99%. Identical residues are shaded in black and structurally conserved residues are boxed. Highly related to PDEδ is hRG4 (hs_RG4; GenBank accession no. U40998), a protein highly expressed in human retina that also has been found in rat (rn_RG4; GenBank accession no. U40999), and C. elegans (unc119; not shown; GenBank accession no. A38976).