Figure 1.
Comparative protein sequences of SKI-1 deduced from rat, mouse, and human cDNAs. The position of the predicted end of the 17-aa signal peptide is shown by an arrow. The active sites Asp218, His249, and Ser414 as well as the oxyanion hole Asn338 are shown as bold, shaded, and underlined characters. The positions of the six potential N-glycosylation sites are emphasized in bold. The conserved shaded sequence fits the consensus signature for growth factors and cytokine receptor family. Each of the two boxed sequences was absent (▾) in a number of rat clones. The predicted transmembrane segment is in bold and underlined.