Figure 1.

Schematic representation of Moco biosynthetic proteins with structural homology to gephyrin. The primary structure of the mammalian polypeptide gephyrin shows striking homology to Moco synthesic proteins from E. coli (MogA and MoeA), invertebrates (cinnamon) and plants (Cnx1). MogA and MogA-like domains are shown as black bars, and MoeA and MoeA-like domains are represented as gray bars. Both domains are connected by a central region showing no significant sequence homology to other proteins. Note that the two domains are inverted in Cnx1.