TABLE 3.
Frequency of mutations in RIF-resistant M. tuberculosis isolates from different geographic regions
| Geographic region (reference; no. of isolates) | Frequency (%) of mutated codons |
|||||
|---|---|---|---|---|---|---|
| Ser-531-Leua | His-526-Aspa | His-526-Tyra | His-516-Vala | Other mutations | No mutation within hot-spot region | |
| Asia (9; n = 77) | 44.2 | 5.2 | 10.4 | 15.6 | 18.1 | 6.5 |
| Australia (24; n = 33) | 48.5 | 12.1 | 12.1 | 6.1 | 18.2 | 3.0 |
| Brazil (21; n = 82) | 50.0 | 1.2 | 11.0 | 6.2 | 28.0 | 3.6 |
| Greece (13; n = 17) | 41.2 | 17.6 | 11.8 | 23.5 | 5.9 | |
| Hungary (1; n = 29) | 31.0 | 6.9 | 37.9 | 13.9 | 10.3 | |
| India (12; n = 44) | 54.5 | 2.3 | 4.5 | 36.4 | 2.3 | |
| Italy (16; n = 37) | 56.7 | 24.3 | 2.7 | 2.7 | 13.6 | |
| United States (23; n = 61) | 34.4 | 8.2 | 27.9 | 4.9 | 16.4 | 8.2 |
| Turkey (n = 41) | 46.3 | 2.4 | 4.9 | 2.4 | 41.5 | 2.4 |
a
Includes frequency of mutations only at a single codon.