TABLE 2.
Overall interpretive agreement between results of fluconazole and voriconazole agar-based susceptibility tests and of standard 48-h BMD reference tests for 235 C. glabrata isolates
Antifungal agent | Method and mediuma | % of isolates by categoryb
|
% of discrepant resultsc
|
% Categorical agreementd | ||||
---|---|---|---|---|---|---|---|---|
S | S-DD | R | Minor | Major | Very major | |||
Fluconazole | BMD | 57 | 36 | 7 | ||||
ET-RPG | 32 | 54 | 14 | 46.0 | 1.7 | 0 | 52.3 | |
ET-MBE | 44 | 44 | 12 | 36.6 | 1.7 | 0 | 61.7 | |
Disk | 90 | 2 | 8 | 34.9 | 0 | 0.4 | 64.7 | |
Voriconazole | BMD | 93 | 7 | |||||
ET-RPG | 92 | 8 | 2.6 | 2.6 | 94.8 | |||
ET-MBE | 93 | 7 | 1.7 | 2.1 | 96.2 | |||
Disk | 94 | 6 | 0.9 | 1.7 | 97.4 |
See footnote a of Table 1 for definitions of BMD, ET-RPG, ET-MBE; disk, disk diffusion test with fluconazole (25-μg disk) and voriconazole (1-μg disk).
Percentage of isolates classified in the different susceptibility categories. See Materials and Methods for definitions.
Percentage of test results with minor, major, or very major discrepancies compared to the results of the reference BMD method at 48 h. See Materials and Methods for definitions.
Agreement rates reflect the percentage of isolates classified in the same category by both the agar-based (Etest and disk) and the reference BMD methods.