Abstract
Samples of chorionic villi were obtained in the first trimester by aspiration using a cannula passed transcervically under the guidance of real time ultrasound. In initial studies in 47 anaesthetised patients immediately before therapeutic abortion a method was developed giving a success rate of 89%. In 10 patients successful sampling was performed as an outpatient procedure without anaesthesia. In all, seven diagnostic procedures were undertaken and four of the five unaffected pregnancies continued. The technique of chorionic villous sampling using real time ultrasound is simple to learn and yields material for biochemical analysis and chromosomal study without the need for tissue culture. The exact obstetric risk, however, remains to be defined.
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- Brambati B., Simoni G. Diagnosis of fetal trisomy 21 in first trimester. Lancet. 1983 Mar 12;1(8324):586–586. [PubMed] [Google Scholar]
- Elliott R. B., Crossley J. R., Berryman C. C., James A. G. Partial preservation of pancreatic beta-cell function in children with diabetes. Lancet. 1981 Jul 4;2(8236):1–4. doi: 10.1016/s0140-6736(81)90249-x. [DOI] [PubMed] [Google Scholar]
- Old J. M., Ward R. H., Petrou M., Karagözlu F., Modell B., Weatherall D. J. First-trimester fetal diagnosis for haemoglobinopathies: three cases. Lancet. 1982 Dec 25;2(8313):1413–1416. doi: 10.1016/s0140-6736(82)91324-1. [DOI] [PubMed] [Google Scholar]
- Ward R. H., Modell B., Fairweather D. V., Shirley I. M., Richards B. A., Hetherington C. P. Obstetric outcome and problems of mid-trimester fetal blood sampling for antenatal diagnosis. Br J Obstet Gynaecol. 1981 Nov;88(11):1073–1080. doi: 10.1111/j.1471-0528.1981.tb01755.x. [DOI] [PubMed] [Google Scholar]