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Growth inhibition of S. cerevisiae with UK-118005 treatment. Growth inhibition by UK-118005 was assayed as described in Materials and Methods. The two mutant strains (•) are more resistant than the wild-type cells (▪), as indicated by at least a fourfold increase in IC50 after 48 h of treatment with UK-118005. (Top panel) diploid strains; (bottom panel) haploid strains. The IC50 is the concentration of compound that inhibits growth by 50%.
