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British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1983 Nov 12;287(6403):1410–1412. doi: 10.1136/bmj.287.6403.1410

Histology of the postoperative stomach before and after diversion of bile.

P C Watt, J M Sloan, A Spencer, T L Kennedy
PMCID: PMC1549640  PMID: 6416436

Abstract

Gastric biopsy specimens were taken in 33 patients before and after procedures to divert bile (construction of Roux loop in 19, closure of gastrojejunostomy in 14). Each biopsy specimen was assessed for dysplasia, intestinal metaplasia, atrophy, and gastritis, each variable being given a score ranging from 0 to 6. Patients were given preoperative and postoperative scores for each of these variables based on the average score of all preoperative or postoperative specimens. Comparison between preoperative and postoperative histology showed that there was no difference for gastritis, atrophy, or intestinal metaplasia. Patients who underwent closure of a gastrojejunostomy showed improvement in dysplasia that was not statistically significant. There was, however, a significant improvement in dysplasia in patients in whom a Roux loop was fashioned (p = 0.006) and in all patients taken together (p = 0.002). It was concluded that procedures that divert bile improve dysplasia but not other histological abnormalities in the stomach postoperatively.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Domellöf L. Gastric carcinoma promoted by alkaline reflux gastritis -- with special reference to bile and other surfactants as promoters of postoperative gastric cancer. Med Hypotheses. 1979 Apr;5(4):463–476. doi: 10.1016/0306-9877(79)90112-9. [DOI] [PubMed] [Google Scholar]
  2. Domellöf L., Reddy B. S., Weisburger J. H. Microflora and deconjugation of bile acids in alkaline reflux after partial gastrectomy. Am J Surg. 1980 Aug;140(2):291–295. doi: 10.1016/0002-9610(80)90024-0. [DOI] [PubMed] [Google Scholar]
  3. Green R., Spencer A., Kennedy T. Closure of gastrojejunostomy for the relief of post-vagotomy symptoms. Br J Surg. 1978 Mar;65(3):161–163. doi: 10.1002/bjs.1800650306. [DOI] [PubMed] [Google Scholar]
  4. Hoare A. M., McLeish A., Thompson H., Alexander-Williams J. Selection of patients for bile diversion surgery: use of bile acid measurement in fasting gastric aspirates. Gut. 1978 Mar;19(3):163–165. doi: 10.1136/gut.19.3.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Keighley M. R., Asquith P., Alexander-Williams J. Duodenogastric reflux: a cause of gastric mucosal hyperaemia and symptoms after operations for peptic ulceration. Gut. 1975 Jan;16(1):28–32. doi: 10.1136/gut.16.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kennedy T., Green R. Roux diversion for bile reflux following gastric surgery. Br J Surg. 1978 May;65(5):323–325. doi: 10.1002/bjs.1800650510. [DOI] [PubMed] [Google Scholar]
  7. Lambert R. Chronic gastritis. A critical study of the progressive atrophy of the gastric mucosa. Digestion. 1972;7(1):83–126. doi: 10.1159/000197264. [DOI] [PubMed] [Google Scholar]
  8. Morson B. C., Sobin L. H., Grundmann E., Johansen A., Nagayo T., Serck-Hanssen A. Precancerous conditions and epithelial dysplasia in the stomach. J Clin Pathol. 1980 Aug;33(8):711–721. doi: 10.1136/jcp.33.8.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mosimann F., Burri B., Diserens H., Fontolliet C., Loup P., Mosimann R. Enterogastric reflux; experimental and clinical study: a preliminary report. Scand J Gastroenterol Suppl. 1981;67:149–152. [PubMed] [Google Scholar]
  10. Reddy B. S., Narasawa T., Weisburger J. H., Wynder E. L. Promoting effect of sodium deoxycholate on colon adenocarcinomas in germfree rats. J Natl Cancer Inst. 1976 Feb;56(2):441–442. doi: 10.1093/jnci/56.2.441. [DOI] [PubMed] [Google Scholar]
  11. Ritchie W. P., Jr Alkaline reflux gastritis. An objective assessment of its diagnosis and treatment. Ann Surg. 1980 Sep;192(3):288–298. doi: 10.1097/00000658-198009000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schrumpf E., Serck-Hanssen A., Stadaas J., Aune S., Myren J., Osnes M. Mucosal changes in the gastric stump 20-25 years after partial gastrectomy. Lancet. 1977 Sep 3;2(8036):467–469. doi: 10.1016/s0140-6736(77)91599-9. [DOI] [PubMed] [Google Scholar]
  13. Schön I. M., Andersson H., Faxén A., Olbe L. Gastric bile acids before and after Roux-en-Y transposition for bile reflux gastritis and in asymptomatic controls. Scand J Gastroenterol. 1979;14(8):969–976. [PubMed] [Google Scholar]
  14. Serck-Hanssen A. Precancerous lesions of the stomach. Scand J Gastroenterol Suppl. 1979;54:104–105. [PubMed] [Google Scholar]
  15. Silen W. Malevolent gall. Surgery. 1972 Feb;71(2):311–312. [PubMed] [Google Scholar]
  16. Siurala M., Isokoski M., Varis K., Kekki M. Prevalence of gastritis in a rural population. Bioptic study of subjects selected at random. Scand J Gastroenterol. 1968;3(2):211–223. doi: 10.3109/00365526809180125. [DOI] [PubMed] [Google Scholar]
  17. Stokkeland M., Schrumpf E., Hanssen A. S., Myren J., Osnes M., Stadaas J. Incidence of malignancies of the Billroth II operated stomach. A prospective follow-up. Scand J Gastroenterol Suppl. 1981;67:169–171. [PubMed] [Google Scholar]
  18. Svensson J. O., Hansson G. Gastric and intestinal mucosal morphology before and after interposition of a reflux-preventing valve between the gastric remnant and the duodenum. An experimental study in dogs. Acta Chir Scand. 1980;146(8):597–603. [PubMed] [Google Scholar]

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