Table 1.
Percentage concordance (no. of trials) of trained mice to urine in training trials and serum in test trials
| Mouse | Dilute
voided urine
|
Untreated serum, generalization‡ | Protease-treated serum generalization | |
|---|---|---|---|---|
| Rewarded | Unrewarded† | |||
| 1 | 87 (179) | 91 (33) | 44 (18) | 53 (15) |
| 2 | 85 (219) | 81 (42) | 61 (23) | 58 (19) |
| 3 | 91 (208) | 95 (43) | 50 (24) | 83 (18)* |
| 4 | 88 (224) | 86 (42) | 68 (22) | 84 (19)* |
| 5 | 84 (201) | 73 (37) | 45 (22) | 87 (15)* |
| 6 | 86 (109) | 90 (21) | 60 (10) | 67 (9) |
| Means | 87 ± 1 | 86 ± 4 | 55 ± 4† | 73 ± 7*† |
Mouse 1 and 5 were reinforced for B6-H-2k; all others were reinforced for B6 (H-2b). Mouse number 6 died before the last tests could be completed.
*
P < 0.005 (null hypothesis = 50%), binomial test (note: only significant serum trials are indicated for individual animals; all individual urine trials are also significant at this level).
†
P < 0.05 (treated > untreated), Wilcoxon test for matched pairs.
‡
For an explanation of the terms “generalization” and “unrewarded,” see Materials and Methods.