TABLE 3.

Molecular epidemiology of EBV infection in healthy individuals

Subject and specimen	Time point (mo)	No. of EBV genome copiesa	EBV LMP-1 genotype(s)b	No. of clones
1
Saliva	0	ND	-	0
Blood	0	ND	-	0
Saliva	2	ND	3c-C	10
Blood	2	ND	-	0
2
Saliva	0	10,400	3c-D	10
Blood	0	ND	-	0
Saliva	2	2,220,000	3c-D	10
Blood	2	ND	-	0
Saliva	4	328,000	3c-D	9
Blood	4	ND	-	0
3
Saliva	0	6	2a-G	8
Blood	0	ND	B958a-B958	10
Saliva	2	ND	3c-D	10
Blood	2	ND	1-G	10
Saliva	6	8	-	0
Blood	6	39	-	0
Saliva	8	14	3c-D	8
Blood	8	ND	-	0
Saliva	10	51	-	0
Blood	10	ND	-	0
4
Saliva	0	81,500	2a-G	10
Blood	0	ND	-	0
Saliva	2	66,700	2a-G	10
Blood	2	ND	-	0
Saliva	4	158,000	2a-G	22
Blood	4	ND	-	0
5
Saliva	0	2,920	B958b-F2	9
Blood	0	ND	-	0
Saliva	2	365	B958b-F2	10
Blood	2	ND	-	0
Saliva	4	4,240	B958b-F2	10
Blood	4	ND	-	0
6
Saliva	0	42	-	0
Blood	0	13	-	0
Saliva	2	17	2a-G	10
Blood	2	ND	-	0
Saliva	4	161	-	0
Blood	4	ND	-	0
7
Saliva	0	14,100	B958b-F2	10
Blood	0	ND	-	0
Saliva	2	15	-	0
Blood	2	ND	-	0
Saliva	4	566	B958b-F2	10
Blood	4	ND	-	0
8
Saliva	0	428	-	0
Blood	0	ND	-	0
Saliva	2	690	3c-D	8
Blood	2	ND	-	0
Saliva	4	4,210	3c-D	10
Blood	4	ND	-	0
9
Saliva	0	350	2a-F2 + 3c-D	8 + 2
Blood	0	80	B958a-B958 + B958b-F2	6 + 4
Saliva	2	276	2a-F2 + 3c-D	3 + 7
Blood	2	ND	-	0
Saliva	8	320	1-G + 2a-F2 + 3c-D	1 + 2 + 6
Blood	8	ND	2a-F2	10

^aIn 0.5 μg of DNA extracted from salivary cells or peripheral blood mononuclear cells. ND, not detectable.

^b-, PCR and cloning unsuccessful.