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(A) A population of LR SA cells (secondary y-axis) allows the population of LR cells to proliferate. Eventually, the LR IA cells replace the LR SA cells, temporarily preventing the development of new vasculature.
(B) In this case, the cells creating the blood supply have additional mutations, allowing the LR IA EA SA population to plateau rather than decline, as occurred in the case of the LR SA cells in (A).
