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(A) Inactive CaMKII docks on the II-III loop of α1H Ca2+ channels poised to sense Ca2+ influx. (B) Depolarization-mediated Ca2+ influx elicits a local rise in Ca2+ and activates CaMKII. (C) Activated CaMKII migrates to S1198 for phosphotransfer. (D) CaMKII phosphorylates S1198, provoking further Ca2+ influx, and then dissociates. Membrane potential is restored, and the cycle begins anew.
