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. 2000 Jul;2(4):339–345. doi: 10.1038/sj.neo.7900105

Figure 4.

Figure 4

FISH preparations of interphase cells of the K1735 clone X-21 cells, treated and untreated with ara-C. Cells are stained with DAPI for DNA (blue), and the telomeric DNA labeled with rhodamine (red). Untreated control cells showing a large quantity of telomeric DNA present (A). Telomeric DNA in bundles being extruded from nuclei of X-21 cells treated with ara-C for 24 and 48 hours (B, C, and D). Large nuclei from ara-C-treated cells showing reduced telomeric signals (E). All microphotographs are made at the same magnification.