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. 2002 Mar;4(2):98–102. doi: 10.1038/sj.neo.7900212

Figure 1.

Figure 1

Representative histology of the rat offspring vagina at estrus. (A) Control (cornstarch-treated animals) group. The vaginal epithelium is formed by 6–10 layers, of which superficial layers are cornified (↓). x400. (B) Rat vagina at estrus. 0.1 mg/kg BPA. No keratinization of the superficial layers (↓). Vaginal epithelium is formed by less then four layers. x400 (C) Rat vagina at estrus. 0.2 mg/kg E2 (positive control). No keratinization at the surface of the epithelium (↓). Slight desquamation of the superficial layers (*). Vaginal epithelium is formed by ≤6 layers. x400. (D) Rat vagina at estrus. 50 mg/kg BPA. Process of slight keratinization at the surface of the superficial layers (↓). Mostly no keratinization can be observed. Vaginal epithelium is formed by ≤6 layers. x400.