Figure 1.

The logarithm of the initialized tumor volumes versus the days of treatment are shown for four experiments. One million LLHM tumor cells were injected into the flanks of mice and grown to an average of 291 mm³ (tumor volumes were calculated by 0.52xlxw². At this point the mice were sorted into their respective groups, and started on TM if appropriate. When the mice in the RT or RT + TM groups reached an average of 522 mm³ (2 days later) they all received RT on the same day to the tumor-injected flanks using a gamma-cell Cs irradiator and specially designed shielding. The number of mice still living are shown for all time points. Statistical analysis was done from days 10–16. The y axis represents the logarithm of the tumor volumes initialized for the starting tumor volume on day 0. All mice getting TM began on day 0. In experiment 1, they received 0.75 mg/mouse per day of TM orally for 15 days, then 0.5 mg/mouse per day for the duration of the experiment. In experiments 2–4, they received 1 mg/mouse per day of TM orally for 2 days, then 0.5 mg/mouse per day for the duration of the experiment.