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UCN-01 downregulation of p21 and 14-3-3σ. UCN-01 downregulates radiation-mediated p21 and 14-3-3σ induction only in p53 proficient cells without affecting p53 protein levels, as shown by Western blot. Radiation induction of p21 and 14-3-3σ in the absence or presence of varying concentration of UCN-01 is indicated. Cells were treated with UCN-01 for 24 hours and then irradiated. Cells were then harvested 24 hours postirradiation. GAPDH was used as a control of loading.
