. Author manuscript; available in PMC: 2007 Apr 1.

Published in final edited form as: Am J Physiol Heart Circ Physiol. 2005 Nov 18;290(4):H1642–H1650. doi: 10.1152/ajpheart.00586.2005

Table 2.

Hemodynamic and metabolic response to injury and resuscitation measured 24 h after septic (or vehicle) challenge and on postburn day 8

	Group 4	Group 5	Group 6	Group 7	Group 8
	Sham Burn + IT Vehicle	Burn + IS + IT Vehicle	Burn + HSD + IT Vehicle	Burn + IS + Sepsis	Burn + HSD + Sepsis
MAP, mmHg	150.6±4.9	145.1±4.1	145.0±5.6	100.9±4.8^*	131.9±6.8^*
HR, beats/min	523±12	505±21	489±16	421±29^*	503±8+
pH	7.47±0.04	7.51±0.01	7.49±0.01	7.51±0.01	7.52±0.01
P_CO₂, mmHg	23.5±1.2	28.4±1.1	26.3±1.1	26.1±1.2	25.3±0.5
Base excess, mM	1.64±0.4	0.52±0.58	−1.2±0.3	−1.7±0.3^*	−1.27±0.4^*
Lactate, mM	2.20±0.3	4.14±0.31^*	2.25±0.14	3.11±0.22^*	2.3±0.2+
Serum ${HCO}_{3}^{-}$ , meq/l	19.5±0.7	22.4±0.6	20.4±0.8	20.1±0.5	20.6±0.5
Hct	42.8±3.0	37.3±1.5	34.9±1.4^*	35.6±1.6^*	34.7±1.7^*
Ca²⁺, mM	1.29±0.01	0.82±0.02^*	0.70±0.04^*	0.85±0.02^*	0.71±0.02^*
Na⁺, mM	141.2±0.6	144.8±0.7	146.3±0.8^*	143.4±0.4	145.7±0.5^*
Plasma TNF-α, pg/ml	4.7±0.3	19±0.2^*	8.4±0.6^*^†	190±0.2^*	10.2±0.9^*^†
Plasma IL-1β, pg/ml	2.3±0.3	14±0.9^*	2.2±0.4^†	140±1^*	3.3±0.7^†
Plasma IL-6, pg/ml	60±4.4	61±0.6	24±1.2^*^†	337±10.2^*	30.1±2.3^*^†

All values are means ± SE. IT, intratracheal; Ca²⁺, serum ionized calcium; Na⁺, serum ionized sodium.

Significant difference from sham burns (P < 0.05)

^†

significant difference between IS- and HSD-treated burns (P < 0.05).