Table 3.

Stabilization data collected 24 h after septic challenge and 8 days after burn during perfusion of hearts at constant preload, constant coronary flow rate, and constant heart rate

	Group 4	Group 5	Group 6	Group 7	Group 8
	Sham Burn + IT Vehicle	Burn + IS + IT Vehicle	Burn + HSD + IT Vehicle	Burn + IS + Sepsis	Burn + HSD + Sepsis
LVP, mmHg	93±5	88±2	91±4	65±4*	80±3*†
+dP/dtmax, mmHg/s	2,021±122	1,965±45	1,938±78	1,320±131*	1,704±69*†
−dP/dtmax, mmHg/s	1,725±126	1,710±52	1,654±72	1,180±142*	1,393±63*†
dP40, mmHg/s	1,792±123	1,775±44	1,706±61	1,140±116*	1,486±56*†
TPP, ms	85.7±1.9	84.7±2.6	94.0±2.0*	91.4±5.8	98.3±3.1
RT90, ms	83.7±1.3	79.3±2.1	90.3±2.7*	88.0±6.0	104.0±3.4
Time to +dP/dtmax, ms	56.3±1.0	56.7±4.9	54.5±1.2	52.6±2.1	57.6±2.1
Time to −dP/dtmax, ms	56.8±1.6	55.2±5.0	54.8±1.2	51.6±2.1	57.1±1.3
CPP, mmHg	55.0±2.8	51.3±5.0	44.3±4.6	44.2±5.9	49.4±4.7
CVR, mmHg/ml	11.0±1.0	10.4±1.0	8.9±0.9	8.84±1.19	9.89±0.95
HR, beats/min	262±15	265±4	250±6	257±14	247±11

All values are means ± SE; dP40, developed pressure at 40 mmHg; TPP, time to peak pressure; RT₉₀, time to 90% relaxation; CPP, coronary perfusion pressure; CVR, coronary vascular resistance.

^*Significant difference from sham burns (P < 0.05)

^†significant difference between IS- and HSD-treated burns (P < 0.05).