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. Author manuscript; available in PMC: 2006 Aug 17.
Published in final edited form as: J Pediatr. 2006 Jan;148(1):23–29. doi: 10.1016/j.jpeds.2005.08.075

Table II, A.

Modeling of changes in BMI with metformin therapy in 26 white children

Parameter ΔBMI (kg/m2) First 4 months 95% CI P ΔBMI (kg/m2) Next 12 months 95% CI P
Baseline (CIRgp 1, CISI 1, female, pubertal) − 2.7 − 4.0, − 1.5 <.001 − 1.6 − 4.8, +1.6 .32
Modifications to the above effects
 For every doubling of CIRgp (secretion) − 0.1 − 0.8, +0.6 .78 − 0.1 − 1.7, +1.6 .94
 For every doubling of CISI (sensitivity) +0.7 +0.1, +1.4 .027 +0.6 1.2, +2.3 .52
 Male sex − 0.2 − 1.7, +1.4 − .82 − 2.4 − 6.0, +1.3 .19
 Prepubertal − 0.3 − 1.7, +1.1 .68 − 0.5 − 3.8, +2.8 .76