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. Author manuscript; available in PMC: 2006 Aug 17.
Published in final edited form as: J Pediatr. 2006 Jan;148(1):23–29. doi: 10.1016/j.jpeds.2005.08.075

Table II, D.

Modeling of changes in BMI z-score with metformin therapy in 17 black children

Parameter ΔBMI z-score First 4 months 95% CI P ΔBMI z-score Next 12 months 95% CI P
Baseline (CIRgp 1, CISI 1, female, pubertal) − 0.04 − 0.17, +0.09 .55 +0.12 − 0.27, +0.51 .53
Modifications to the above effects
 For every doubling of CIRgp (secretion) − 0.04 − 0.10, +0.02 .18 − 0.04 − 0.22, +0.15 .68
 For every doubling of CISI (sensitivity) − 0.04 − 0.13, +0.05 .34 − 0.09 − 0.34, +0.17 .47
 Male sex +0.21 − 0.14, +0.56 .21 − 0.58 − 2.68, +1.52 .56
 Prepubertal +0.11 − 0.04, +0.25 .13 − 0.07 − 0.48, +0.34 .73