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Model depicting role of activated Cdc28 (Cdk1) in SPB separation in budding yeast. Tyrosine dephosphorylation of Cdc28 by Mih1 leads to inactivation of Cdh1 resulting in stabilization of microtubule-associated proteins Cin8, Kip1 and Ase1 whose bundling activity catalyzes SPB separation and formation of the bipolar mitotic spindle.
