Figure 11.

Adoptive transfer of naive bone marrow–derived DCs bypasses CD137-induced suppression. One million NZB/W F₁ bone marrow–derived CD11c⁺ DCs (15–30% CD137⁺) were injected i.v. into 26-week-old NZB/W F₁ mice (n = 10) that had been injected with anti-CD137 mAb’s 4 weeks earlier. The mice were bled weekly, and anti-dsDNA titers were determined as above.