Figure 3.

Anti-CD137 mAb treatment blocks germinal center reactions. NZB/W F₁ mice were injected once every third week with anti-CD137 or isotype-matched control mAb’s beginning at 14 weeks of age and continuing through 26 weeks of age. The mice were euthanized, and spleens were removed for thin sectioning and H&E staining. Sections were viewed with ×20 and ×40 objectives and photographed. (a and c) Representative fields at ×20 and ×40, respectively, of mice injected with isotype-matched control mAb’s. (b and d) Representative fields at ×20 and ×40, respectively, of mice treated with anti-CD137 mAb’s. Bar, 100 μg.