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Anti-CD137 mAb’s do not suppress established anti-SRBC humoral immune responses. Five 26-week-old NZB/W F1 mice were immunized with SRBC and boosted at 28 weeks of age. At 30 weeks of age, the mice were injected with 200 μg anti-CD137 mAb’s intraperitoneally. Serum from the mice was collected at various time points after treatment and assayed by ELISA for anti-SRBC (triangles) or anti-dsDNA (circles) antibodies.
