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AP phenotype is determined by IK1 density. (a) Stable APs evoked by depolarizing external stimuli in control myocytes. (b) APs recorded in overexpressed myocytes with a robust IK1 are abbreviated. (c) In Kir2.1AAA-transduced myocytes with moderately depressed IK1, APs with a long-QT phenotype were evoked. The actual IK1 density measurements from the individual myocytes comprising each group are plotted to the right of each AP waveform.
