Table 2.
Association between risk of NPC and XRCC1 genotypes among cases and controls
| Genotype | Cases No. (%)a | Controls No. (%)b | Unadjusted OR | Adjusted ORc (95%CI) | P value |
| XRCC1 Arg194Trp | |||||
| Arg/Arg | 232(55.7) | 235 (47.5) | 1.00 | 1.00 | |
| Arg/Trp | 166(39.8) | 217(43.8) | 0.80 | 0.79(0.60–1.05) | 0.10 |
| Trp/Trp | 19(4.5) | 43(8.7) | 0.48 | 0.48(0.27–0.86) | 0.01* |
| Allele of Trp | 0.24 | 0.31 | |||
| XRCC1 Arg399Gln | |||||
| Arg/Arg | 241(56.7) | 270(53.9) | 1.00 | 1.00 | |
| Arg/Gln | 152(35.8) | 201(40.1) | 0.81 | 0.82(0.62–1.08) | 0.16 |
| Gln/Gln | 32(7.5) | 30(6.0) | 1.20 | 1.20(0.69–2.06) | 0.53 |
| Allele of Gln | 0.25 | 0.26 | |||
a 417 cases and 495 controls were eligible tested in condon 194 genotype variant.
b 425 cases and 501 controls were eligible tested in condon 399 genotype variant.
c Adjusted OR were calculated with the XRCC1 194Arg/Arg or 399Arg/Arg genotype as the reference group and adjusted for age, sex, smoking status.
*P-value remained significant after Bonferroni's correction.